Job Description

Job Title: Director Next-Generation Sequencing - Biologics Engineering
Location: Gaithersburg, MD

At AstraZeneca, we pride ourselves on crafting a collaborative culture that champions knowledge-sharing, ambitious thinking and innovation – ultimately providing employees with the opportunity to work across teams, functions and even the globe. 

Recognizing the importance of individualized flexibility, our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week . Our head office is purposely designed with collaboration in mind, providing space where teams can come together to strategize, brainstorm and connect on key projects. 

Our dedication to sustainability is also central to our culture and part of what makes AstraZeneca a great place to work. We know the health of people, the planet and our business are interconnected which is why we’re taking ambitious action to tackle some of the biggest challenges of our time, from climate change to access to healthcare and disease prevention. 

Introduction to Role:

We are seeking a visionary and experienced Director to lead and transform our Next-Generation Sequencing (NGS) capabilities within the Biologics Engineering department at AstraZeneca. This key leadership position will drive the implementation of cutting-edge NGS technologies, automation processes, and data analysis workflows specifically tailored for antibody discovery and engineering as well as support Therapeutics Areas in R&D across our global organization.

The ideal candidate will possess a strong understanding of both NGS technologies and the needs of teams focusing on Artificial Intelligence (AI). A critical aspect of this role is ensuring that the data generated from NGS processes are optimized to feed into AI pipelines, fostering a synergistic relationship between NGS and AI-driven drug discovery and development.

Accountabilities:

Strategic Leadership and Vision: 

• Develop and execute a comprehensive strategy for specialized NGS applications in antibody discovery, focusing on overcoming the unique challenges posed by high sequence similarity in antibody repertoires. 
• Drive the holistic strategy for NGS utilization in support of Biologics Engineering activities and Therapeutic Areas with focus on design and optimization of custom NGS workflows for antibody repertoire sequencing and AI-driven research initiatives. 
• Lead the integration of NGS into discovery workflows (in-vivo and in-vitro), emphasizing data generation for machine learning applications. 

Team Leadership and Development: 

• Lead, mentor, and develop a high-performing team of scientists, fostering a culture of innovation that bridges the gap between traditional NGS approaches and emerging AI technologies in the field of biologics engineering. 
• Attract and retain top talent in the fields of NGS and bioinformatics. 

Technological Innovation: 

• Spearhead the evaluation, adoption, and optimization of emerging sequencing technologies to enhance AstraZeneca's research capabilities in support of Antibody and TCR discovery within the Biologics Engineering unit. 
• Collaborate closely with AI teams to understand their data requirements and ensure that NGS outputs are structured and formatted to seamlessly integrate with AI algorithms and machine learning models. 
• Develop and implement advanced bioinformatics pipelines specifically designed for antibody sequence analysis, including tools for repertoire analysis, lineage tracing, and affinity maturation studies. 
• Drive the integration of automation in sample preparation, library construction, and NGS workflows to increase efficiency, reproducibility, and throughput. 

Data Strategy and Bioinformatics: 

• Develop and implement robust data analysis pipelines and bioinformatics workflows to support various NGS applications in biologics R&D. 
• Collaborate with computational scientists to integrate NGS data with other omics approaches and drive data-driven decision making in biologics discovery. 

Cross-functional Collaboration: 

• Align NGS strategies and capabilities with the Biologics Engineering team in Cambridge, UK, and support operations at the Waltham site. 
• Foster strong partnerships with Therapeutic Areas in R&D and NGS teams in oncology and translational medicine. 
• Manage relationships with key stakeholders across the organization to ensure alignment of NGS capabilities with Biologics Engineering and organizational needs. 

Global Leadership: 

• Establish and maintain AstraZeneca's position as a world leader in NGS applications for biologics discovery and development. 
• Represent AstraZeneca at international conferences and collaborate with academic institutions and industry partners to stay at the forefront of NGS technologies and applications. 

Resource Management: 

• Oversee budget management, resource allocation, and strategic planning for the NGS Team within the Biologics Engineering department. 
• Manage external collaborations and partnerships to expand technical expertise and access resources. 

Essential Skills/Experience:

• Ph.D. in Molecular Biology, Genetics, Bioinformatics, or a related field with 7+ years of relevant experience in NGS technologies and applications within the pharmaceutical or biotechnology industry. 
• Demonstrated success in leading and managing scientific teams, with a track record of fostering innovation and driving strategic initiatives. 
• Extensive hands-on experience with various NGS platforms (e.g. Illumina, PacBio, ONT) and their applications in biologics research, including emerging technologies. 
• Strong background in laboratory automation and high-throughput genomics workflows. 
• Expertise in bioinformatics and data analysis, including: 
• Proficiency in Python and R programming languages 
• Experience  building scalable and reproducible scientific workflows 
• Understanding of cloud computing services for bioinformatics applications 

• Strong understanding of antibody discovery processes and biologics development. 
• Excellent communication and interpersonal skills, with the ability to influence and collaborate effectively across all levels of the organization. 

Total Rewards:

The annual base pay for this position ranges from $172,672.00 - $259,008.00. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.  In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. 

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